275 AD
The Kaftir inscription at Naqsh-I-Rustam mention religious groups that are persecuted at the hands of the Sassanians.

272 AD
This is the date associated with one of the earliest known Mandaean copyists named Zazai d-Gawazta, son of Hawa. He is the earliest copyist on the following: The Thousand and Twelve Questions, Alma Risaia Zuta , Diwan Masbuta d-Hibil Ziwa, Qolasta, and he is mention in the Abahatan Qadmaiia . The language at this time represents a fully developed Babylonian-Aramaic idiom and a poetic skill that has never been match or surpassed in any later Mandaean literature. The classical period ends with the redaction of the Ginza in the first Muslim century.

224 AD
The Mandaeans suffer persecution under the Sassanians (Persian dynasty 224 AD TO 640 AD)

200's AD
Mani is born and begins his religion of Manichaeanism--Mandaean material is used in the creation of this new religion.

160 to 235 AD
Life of Hippolytus
Hippolytus tells of a book obtained by a man called "Elchasai". He got this book from Serae, a town of Parthia , and that he gave this to the Sobiai (assumed to be the Mandaeans). More than likely this person Elchasai received the book from the Sobiai (Mandaeans).

81 BC –224 AD
Kingdom of Elymais existed in which there is a form of script copied from the Mandaic. This form is called Elymaean and is considered by Macuch to be a late form of Mandaic instead of an earlier form. The main writing comes from a few inscriptions found in Khuzistan at Tang-e Sarvak and the Shimbar Valley .